Canwest’s E! is celebrating its first anniversary by kicking off its fall season with four new series. Do Not Disturb, starring Jerry O’Connell (Crossing Jordan), premieres on Monday, Sept. 8 at 9 pm ET/PT. The comedy is set in a hip New York hotel complete with chic décor and a celebrity clientele.

Worst Week is another comedy set to debut on E! Starring Kyle Bornheimer (Jericho) and Erinn Hayes (Kitchen Confidential), the show follows a magazine editor who becomes a one-man wrecking crew whenever he’s around his girlfriend’s parents. The show premieres on Monday, Sept. 22 at 9:30 pm ET/PT.

Knight Rider bows on Wednesday, Sept. 24 at 8 pm ET/PT. The modern-day remake, starring Justin Bruening (pictured – Cold Case) and Deanna Russo (NCIS), pairs two childhood friends with a new and improved KITT (Knight Industries Three Thousand) – a car that helps the friends thwart villains with its sophisticated technology.

Molly Shannon (Saturday Night Live) and Selma Blair (Hellboy) star in Kath & Kim. The comedy, which premieres on Thursday, Oct. 9 at 8:30 pm ET/PT, follows along with a dysfunctional mother/daughter duo living in suburbia.

E! has also announced season premiere dates for some returning favourites. The sixth season of The Biggest Loser kicks off on Monday, Sept. 16 at 8 pm ET/PT with a two-hour season premiere. How I Met Your Mother season four is set to debut on Monday, Sept. 22 at 8:30 pm ET/PT, along with season five of Boston Legal at 10 pm ET/PT.

My Name is Earl returns to E! for its fourth season on Thursday, Sept. 25 at 8 pm ET/PT, and Extreme Makeover: Home Edition kicks off its sixth season on Sunday, Sept. 28 at 7 pm ET/PT with a two-hour season premiere.